Regioselective Benzoylation of Diols and Carbohydrates by Catalytic Amounts of Organobase.
نویسندگان
چکیده
A novel metal-free organobase-catalyzed regioselective benzoylation of diols and carbohydrates has been developed. Treatment of diol and carbohydrate substrates with 1.1 equiv. of 1-benzoylimidazole and 0.2 equiv. of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in MeCN under mild conditions resulted in highly regioselective benzoylation for the primary hydroxyl group. Importantly, compared to most commonly used protecting bulky groups for primary hydroxyl groups, the benzoyl protective group offers a new protection strategy.
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ورودعنوان ژورنال:
- Molecules
دوره 21 5 شماره
صفحات -
تاریخ انتشار 2016